The Structure of Desmosome
نویسنده
چکیده
Pemphigus (from the Greek pemphix, meaning bubble or blister) is a blistering disease involving the skin and mucous membrane. The disease is characterized histologically by acantholysis which means loss of adhesion between keratinocytes, and immuno-pathologically by the presence of immunoglobulin directed towards the cell surface of kerat inocytes . 1 The landmark ar t ic le in the understanding of pathogenesis of pemphigus was published in 1964, which demonstrated the presence of anti-skin antibodies in the sera of pemphigus patients by indirect immunofluorescence staining. Since then, with the improvement in immunological techniques, the antigens responsible for the disease were identified. These medical advances not only provide us with a better knowledge of the pathogenesis of pemphigus but also lead to the development of recombinant proteins, which are employed in enzyme linked immunosorbent assay (ELISA) for the diagnosis of pemphigus. Review on Pathogenesis of Pemphigus
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Ultrastructure of Desmosomes in Mammalian Intercalated Disc; Appearances after Lanthanum Treatment
At points of desmosomal contact between cells a suggestion of intercellular cross-connections has been reported (1) and an electron-opaque line is often seen midway between the apposed membranes (2, 3), but the nature of this and other extracellular components of the desmosome is still uncertain . The use of lanthanum as an extracellular marker (4) has provided new information about the structu...
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Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament cytoskeleton. Alterations in assembly and disassembly compromise desmosome function and may contribute to human diseases, such as the autoimmune ski...
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